Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
Identifieur interne : 006F12 ( Main/Exploration ); précédent : 006F11; suivant : 006F13Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
Auteurs : Santosh Rudrawar [Australie] ; Jeffrey C. Dyason [Australie] ; Marie-Anne Rameix-Welti [France] ; Faith J. Rose [Australie] ; Philip S. Kerry [Royaume-Uni] ; Rupert J. M. Russell [Royaume-Uni] ; Sylvie Van Der Werf [France] ; Robin J. Thomson [Australie] ; Nadia Naffakh [France] ; Mark Von Itzstein [Australie]Source :
- Nature Communications [ 2041-1723 ] ; 2010.
Abstract
Influenza virus sialidase has an essential role in the virus' life cycle. Two distinct groups of influenza A virus sialidases have been established, that differ in the flexibility of the '150-loop', providing a more open active site in the
Url:
DOI: 10.1038/ncomms1114
PubMed: 21081911
PubMed Central: 3060605
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000111
- to stream Pmc, to step Curation: 000111
- to stream Pmc, to step Checkpoint: 002514
- to stream Ncbi, to step Merge: 000926
- to stream Ncbi, to step Curation: 000926
- to stream Ncbi, to step Checkpoint: 000926
- to stream Main, to step Merge: 007410
- to stream Main, to step Curation: 006F12
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase</title><author><name sortKey="Rudrawar, Santosh" sort="Rudrawar, Santosh" uniqKey="Rudrawar S" first="Santosh" last="Rudrawar">Santosh Rudrawar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dyason, Jeffrey C" sort="Dyason, Jeffrey C" uniqKey="Dyason J" first="Jeffrey C." last="Dyason">Jeffrey C. Dyason</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rameix Welti, Marie Anne" sort="Rameix Welti, Marie Anne" uniqKey="Rameix Welti M" first="Marie-Anne" last="Rameix-Welti">Marie-Anne Rameix-Welti</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Département de Virologie</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS URA3015</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Université Paris Diderot</institution>, Paris F-75013,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Faith J" sort="Rose, Faith J" uniqKey="Rose F" first="Faith J." last="Rose">Faith J. Rose</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerry, Philip S" sort="Kerry, Philip S" uniqKey="Kerry P" first="Philip S." last="Kerry">Philip S. Kerry</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Interdisciplinary Centre for Human and Avian Influenza Research, University of St Andrews</institution>, North Haugh, St Andrews, Fife KY16 9ST,<country>UK</country>.</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Russell, Rupert J M" sort="Russell, Rupert J M" uniqKey="Russell R" first="Rupert J. M." last="Russell">Rupert J. M. Russell</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Interdisciplinary Centre for Human and Avian Influenza Research, University of St Andrews</institution>, North Haugh, St Andrews, Fife KY16 9ST,<country>UK</country>.</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Département de Virologie</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS URA3015</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Université Paris Diderot</institution>, Paris F-75013,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomson, Robin J" sort="Thomson, Robin J" uniqKey="Thomson R" first="Robin J." last="Thomson">Robin J. Thomson</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Département de Virologie</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS URA3015</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Université Paris Diderot</institution>, Paris F-75013,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Von Itzstein, Mark" sort="Von Itzstein, Mark" uniqKey="Von Itzstein M" first="Mark" last="Von Itzstein">Mark Von Itzstein</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21081911</idno><idno type="pmc">3060605</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060605</idno><idno type="RBID">PMC:3060605</idno><idno type="doi">10.1038/ncomms1114</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000111</idno><idno type="wicri:Area/Pmc/Curation">000111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000111</idno><idno type="wicri:Area/Pmc/Checkpoint">002514</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002514</idno><idno type="wicri:Area/Ncbi/Merge">000926</idno><idno type="wicri:Area/Ncbi/Curation">000926</idno><idno type="wicri:Area/Ncbi/Checkpoint">000926</idno><idno type="wicri:Area/Main/Merge">007410</idno><idno type="wicri:Area/Main/Curation">006F12</idno><idno type="wicri:Area/Main/Exploration">006F12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase</title><author><name sortKey="Rudrawar, Santosh" sort="Rudrawar, Santosh" uniqKey="Rudrawar S" first="Santosh" last="Rudrawar">Santosh Rudrawar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dyason, Jeffrey C" sort="Dyason, Jeffrey C" uniqKey="Dyason J" first="Jeffrey C." last="Dyason">Jeffrey C. Dyason</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rameix Welti, Marie Anne" sort="Rameix Welti, Marie Anne" uniqKey="Rameix Welti M" first="Marie-Anne" last="Rameix-Welti">Marie-Anne Rameix-Welti</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Département de Virologie</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS URA3015</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Université Paris Diderot</institution>, Paris F-75013,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rose, Faith J" sort="Rose, Faith J" uniqKey="Rose F" first="Faith J." last="Rose">Faith J. Rose</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerry, Philip S" sort="Kerry, Philip S" uniqKey="Kerry P" first="Philip S." last="Kerry">Philip S. Kerry</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Interdisciplinary Centre for Human and Avian Influenza Research, University of St Andrews</institution>, North Haugh, St Andrews, Fife KY16 9ST,<country>UK</country>.</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Russell, Rupert J M" sort="Russell, Rupert J M" uniqKey="Russell R" first="Rupert J. M." last="Russell">Rupert J. M. Russell</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Interdisciplinary Centre for Human and Avian Influenza Research, University of St Andrews</institution>, North Haugh, St Andrews, Fife KY16 9ST,<country>UK</country>.</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Département de Virologie</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS URA3015</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Université Paris Diderot</institution>, Paris F-75013,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomson, Robin J" sort="Thomson, Robin J" uniqKey="Thomson R" first="Robin J." last="Thomson">Robin J. Thomson</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Département de Virologie</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a3"><institution>CNRS URA3015</institution>, Paris F-75015,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Université Paris Diderot</institution>, Paris F-75013,<country>France</country>.</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Von Itzstein, Mark" sort="Von Itzstein, Mark" uniqKey="Von Itzstein M" first="Mark" last="Von Itzstein">Mark Von Itzstein</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Institute for Glycomics, Gold Coast Campus, Griffith University</institution>, Queensland 4222,<country>Australia</country>.</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza virus sialidase has an essential role in the virus' life cycle. Two distinct groups of influenza A virus sialidases have been established, that differ in the flexibility of the '150-loop', providing a more open active site in the <italic>apo</italic> form of the group-1 compared to group-2 enzymes. In this study we show, through a multidisciplinary approach, that novel sialic acid-based derivatives can exploit this structural difference and selectively inhibit the activity of group-1 sialidases. We also demonstrate that group-1 sialidases from drug-resistant mutant influenza viruses are sensitive to these designed compounds. Moreover, we have determined, by protein X-ray crystallography, that these inhibitors lock open the group-1 sialidase flexible 150-loop, in agreement with our molecular modelling prediction. This is the first direct proof that compounds may be developed to selectively target the pandemic A/H1N1, avian A/H5N1 and other group-1 sialidase-containing viruses, based on an open 150-loop conformation of the enzyme.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zambon, M C" uniqKey="Zambon M">M. C. Zambon</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, S J" uniqKey="Sullivan S">S. J. Sullivan</name></author><author><name sortKey="Jacobson, R M" uniqKey="Jacobson R">R. M. Jacobson</name></author><author><name sortKey="Dowdle, W R" uniqKey="Dowdle W">W. R. Dowdle</name></author><author><name sortKey="Poland, G A" uniqKey="Poland G">G. A. Poland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wagner, R" uniqKey="Wagner R">R. Wagner</name></author><author><name sortKey="Matrosovich, M" uniqKey="Matrosovich M">M. Matrosovich</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.- D. Klenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, R J" uniqKey="Russell R">R. J. Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M. von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M. von Itzstein</name></author><author><name sortKey="Thomson, R J" uniqKey="Thomson R">R. J. Thomson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E. De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, W H" uniqKey="Wen W">W. H. Wen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohan, S" uniqKey="Mohan S">S. Mohan</name></author><author><name sortKey="Mcatamney, S" uniqKey="Mcatamney S">S. McAtamney</name></author><author><name sortKey="Haselhorst, T" uniqKey="Haselhorst T">T. Haselhorst</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M. von Itzstein</name></author><author><name sortKey="Pinto, B M" uniqKey="Pinto B">B. M. Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nolan, S P" uniqKey="Nolan S">S. P. Nolan</name></author><author><name sortKey="Clavier, H" uniqKey="Clavier H">H. Clavier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rameix Welti, M A" uniqKey="Rameix Welti M">M. A. Rameix-Welti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okamoto, K" uniqKey="Okamoto K">K. Okamoto</name></author><author><name sortKey="Kondo, T" uniqKey="Kondo T">T. Kondo</name></author><author><name sortKey="Goto, T" uniqKey="Goto T">T. Goto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paulsen, H" uniqKey="Paulsen H">H. Paulsen</name></author><author><name sortKey="Matschulat, P" uniqKey="Matschulat P">P. Matschulat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholl, M" uniqKey="Scholl M">M. Scholl</name></author><author><name sortKey="Ding, S" uniqKey="Ding S">S. Ding</name></author><author><name sortKey="Lee, C W" uniqKey="Lee C">C. W. Lee</name></author><author><name sortKey="Grubbs, R H" uniqKey="Grubbs R">R. H. Grubbs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okomo Adhiambo, M" uniqKey="Okomo Adhiambo M">M. Okomo-Adhiambo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurt, A C" uniqKey="Hurt A">A. C. Hurt</name></author><author><name sortKey="Holien, J K" uniqKey="Holien J">J. K. Holien</name></author><author><name sortKey="Parker, M" uniqKey="Parker M">M. Parker</name></author><author><name sortKey="Kelso, A" uniqKey="Kelso A">A. Kelso</name></author><author><name sortKey="Barr, I G" uniqKey="Barr I">I. G. Barr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaro, R E" uniqKey="Amaro R">R. E. Amaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, N R" uniqKey="Taylor N">N. R. Taylor</name></author><author><name sortKey="Von Itzstein, M" uniqKey="Von Itzstein M">M. von Itzstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaro, R E" uniqKey="Amaro R">R. E. Amaro</name></author><author><name sortKey="Cheng, X" uniqKey="Cheng X">X. Cheng</name></author><author><name sortKey="Ivanov, I" uniqKey="Ivanov I">I. Ivanov</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author><author><name sortKey="Mccammon, J A" uniqKey="Mccammon J">J. A. McCammon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guex, N" uniqKey="Guex N">N. Guex</name></author><author><name sortKey="Peitsch, M C" uniqKey="Peitsch M">M. C. Peitsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartshorn, M J" uniqKey="Hartshorn M">M. J. Hartshorn</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Goodsell, D S" uniqKey="Goodsell D">D. S. Goodsell</name></author><author><name sortKey="Morris, G M" uniqKey="Morris G">G. M. Morris</name></author><author><name sortKey="Olson, A J" uniqKey="Olson A">A. J. Olson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanner, M F" uniqKey="Sanner M">M. F. Sanner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, L S" uniqKey="Cheng L">L. S. Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Potier, M" uniqKey="Potier M">M. Potier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrosovich, M" uniqKey="Matrosovich M">M. Matrosovich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrosovich, M" uniqKey="Matrosovich M">M. Matrosovich</name></author><author><name sortKey="Matrosovich, T" uniqKey="Matrosovich T">T. Matrosovich</name></author><author><name sortKey="Garten, W" uniqKey="Garten W">W. Garten</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H. D. Klenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pflugrath, J W" uniqKey="Pflugrath J">J. W. Pflugrath</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Adams, P D" uniqKey="Adams P">P. D. Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, T A" uniqKey="Jones T">T. A. Jones</name></author><author><name sortKey="Zou, J Y" uniqKey="Zou J">J. Y. Zou</name></author><author><name sortKey="Cowan, S W" uniqKey="Cowan S">S. W. Cowan</name></author><author><name sortKey="Kjeldgaard, M" uniqKey="Kjeldgaard M">M. Kjeldgaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emsley, P" uniqKey="Emsley P">P. Emsley</name></author><author><name sortKey="Cowtan, K" uniqKey="Cowtan K">K. Cowtan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Rudrawar, Santosh" sort="Rudrawar, Santosh" uniqKey="Rudrawar S" first="Santosh" last="Rudrawar">Santosh Rudrawar</name></noRegion><name sortKey="Dyason, Jeffrey C" sort="Dyason, Jeffrey C" uniqKey="Dyason J" first="Jeffrey C." last="Dyason">Jeffrey C. Dyason</name><name sortKey="Rose, Faith J" sort="Rose, Faith J" uniqKey="Rose F" first="Faith J." last="Rose">Faith J. Rose</name><name sortKey="Thomson, Robin J" sort="Thomson, Robin J" uniqKey="Thomson R" first="Robin J." last="Thomson">Robin J. Thomson</name><name sortKey="Von Itzstein, Mark" sort="Von Itzstein, Mark" uniqKey="Von Itzstein M" first="Mark" last="Von Itzstein">Mark Von Itzstein</name></country><country name="France"><noRegion><name sortKey="Rameix Welti, Marie Anne" sort="Rameix Welti, Marie Anne" uniqKey="Rameix Welti M" first="Marie-Anne" last="Rameix-Welti">Marie-Anne Rameix-Welti</name></noRegion><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><name sortKey="Rameix Welti, Marie Anne" sort="Rameix Welti, Marie Anne" uniqKey="Rameix Welti M" first="Marie-Anne" last="Rameix-Welti">Marie-Anne Rameix-Welti</name><name sortKey="Rameix Welti, Marie Anne" sort="Rameix Welti, Marie Anne" uniqKey="Rameix Welti M" first="Marie-Anne" last="Rameix-Welti">Marie-Anne Rameix-Welti</name><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Kerry, Philip S" sort="Kerry, Philip S" uniqKey="Kerry P" first="Philip S." last="Kerry">Philip S. Kerry</name></noRegion><name sortKey="Russell, Rupert J M" sort="Russell, Rupert J M" uniqKey="Russell R" first="Rupert J. M." last="Russell">Rupert J. M. Russell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006F12 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006F12 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3060605
|texte= Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21081911" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |